Incidence, medical and socio-behavioural predictors of psychiatric events in an 11-year follow-up of HIV-infected patients on antiretroviral therapy.
Identifieur interne : 001584 ( Main/Exploration ); précédent : 001583; suivant : 001585Incidence, medical and socio-behavioural predictors of psychiatric events in an 11-year follow-up of HIV-infected patients on antiretroviral therapy.
Auteurs : Camelia Protopopescu [France] ; François Raffi ; Cécile Brunet-François ; Dominique Salmon ; Renaud Verdon ; Philippe Reboud ; Maria Patrizia Carrieri ; Catherine Leport ; Bruno Spire ; Laurent MichelSource :
- Antiviral therapy [ 2040-2058 ] ; 2012.
Descripteurs français
- KwdFr :
- Adulte (MeSH), Adulte d'âge moyen (MeSH), Association de médicaments (méthodes), Charge virale (MeSH), Comportement social (MeSH), Dépression (psychologie), Dépression (épidémiologie), Enquêtes et questionnaires (MeSH), Facteurs de risque (MeSH), Femelle (MeSH), France (épidémiologie), Humains (MeSH), Incidence (MeSH), Infections à VIH (psychologie), Infections à VIH (épidémiologie), Inhibiteurs de protéase du VIH (pharmacologie), Modèles des risques proportionnels (MeSH), Mâle (MeSH), Numération des lymphocytes CD4 (MeSH), Résultat thérapeutique (MeSH), Suicide (psychologie), Suicide (statistiques et données numériques), VIH (Virus de l'Immunodéficience Humaine) (pathogénicité), Études de suivi (MeSH), Études longitudinales (MeSH).
- MESH :
- méthodes : Association de médicaments.
- pathogénicité : VIH (Virus de l'Immunodéficience Humaine).
- pharmacologie : Inhibiteurs de protéase du VIH.
- psychologie : Dépression, Infections à VIH, Suicide.
- statistiques et données numériques : Suicide.
- épidémiologie : Dépression, France, Infections à VIH.
- Adulte, Adulte d'âge moyen, Charge virale, Comportement social, Enquêtes et questionnaires, Facteurs de risque, Femelle, Humains, Incidence, Modèles des risques proportionnels, Mâle, Numération des lymphocytes CD4, Résultat thérapeutique, Études de suivi, Études longitudinales.
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Adult (MeSH), CD4 Lymphocyte Count (MeSH), Depression (epidemiology), Depression (psychology), Drug Therapy, Combination (methods), Female (MeSH), Follow-Up Studies (MeSH), France (epidemiology), HIV (pathogenicity), HIV Infections (epidemiology), HIV Infections (psychology), HIV Protease Inhibitors (pharmacology), Humans (MeSH), Incidence (MeSH), Longitudinal Studies (MeSH), Male (MeSH), Middle Aged (MeSH), Proportional Hazards Models (MeSH), Risk Factors (MeSH), Social Behavior (MeSH), Suicide (psychology), Suicide (statistics & numerical data), Surveys and Questionnaires (MeSH), Treatment Outcome (MeSH), Viral Load (MeSH).
- MESH :
- chemical , pharmacology : HIV Protease Inhibitors.
- geographic , epidemiology : France.
- epidemiology : Depression, HIV Infections.
- methods : Drug Therapy, Combination.
- pathogenicity : HIV.
- psychology : Depression, HIV Infections, Suicide.
- statistics & numerical data : Suicide.
- Adult, CD4 Lymphocyte Count, Female, Follow-Up Studies, Humans, Incidence, Longitudinal Studies, Male, Middle Aged, Proportional Hazards Models, Risk Factors, Social Behavior, Surveys and Questionnaires, Treatment Outcome, Viral Load.
Abstract
BACKGROUND
Psychiatric disorders are relatively common among HIV-infected patients. However, there are few studies about their potential risk factors. This analysis aimed to measure the incidence of severe psychiatric events (PE) among patients receiving combination antiretroviral therapy (cART) of the French APROCO-COPILOTE (ANRS CO8) cohort, and to identify the medical and socio-behavioural correlates of their first episode of depression, suicide or suicide attempt (D/S/SA).
METHODS
APROCO-COPILOTE is a cohort of patients started on a protease inhibitor regimen between 1997 and 1999, with prospective medical standardized records and self-administered questionnaires collecting socio-demographic and socio-behavioural data. This analysis included all 11-year follow-up visits for 1,095 patients having completed baseline self-administered questionnaires. A proportional hazard Cox model was used to identify the correlates of a first D/S/SA event.
RESULTS
The overall prevalence of severe PE remained low: 50 patients experienced 67 events (incidence rate [95% CI] =1.04 [0.82, 1.32] per 100 person-years). Depression (n=16), suicides (n=5) and suicide attempts (n=14) were the most frequently diagnosed PE (0.54 [0.39, 0.76] per 100 person-years) among 25 patients. Multivariate results showed that unemployment, unstable housing, detectable viral load and smoking more than 20 cigarettes/day were independently associated with D/S/SA.
CONCLUSIONS
Although the incidence of severe PE remained relatively low among the patients of APROCO-COPILOTE cohort, this study's results underline a clinically important problem in HIV-infected patients receiving cART. Furthermore, our findings not only emphasize the importance of comprehensive care, especially for socially vulnerable patients, but may also help future studies designed to assess the effectiveness of interventions in reducing the risk of PE during cART.
DOI: 10.3851/IMP2102
PubMed: 22544079
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Incidence, medical and socio-behavioural predictors of psychiatric events in an 11-year follow-up of HIV-infected patients on antiretroviral therapy.</title>
<author><name sortKey="Protopopescu, Camelia" sort="Protopopescu, Camelia" uniqKey="Protopopescu C" first="Camelia" last="Protopopescu">Camelia Protopopescu</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM, U912 (SESSTIM), Marseille, France. camelia.protopopescu@inserm.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U912 (SESSTIM), Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raffi, Francois" sort="Raffi, Francois" uniqKey="Raffi F" first="François" last="Raffi">François Raffi</name>
</author>
<author><name sortKey="Brunet Francois, Cecile" sort="Brunet Francois, Cecile" uniqKey="Brunet Francois C" first="Cécile" last="Brunet-François">Cécile Brunet-François</name>
</author>
<author><name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name>
</author>
<author><name sortKey="Verdon, Renaud" sort="Verdon, Renaud" uniqKey="Verdon R" first="Renaud" last="Verdon">Renaud Verdon</name>
</author>
<author><name sortKey="Reboud, Philippe" sort="Reboud, Philippe" uniqKey="Reboud P" first="Philippe" last="Reboud">Philippe Reboud</name>
</author>
<author><name sortKey="Carrieri, Maria Patrizia" sort="Carrieri, Maria Patrizia" uniqKey="Carrieri M" first="Maria Patrizia" last="Carrieri">Maria Patrizia Carrieri</name>
</author>
<author><name sortKey="Leport, Catherine" sort="Leport, Catherine" uniqKey="Leport C" first="Catherine" last="Leport">Catherine Leport</name>
</author>
<author><name sortKey="Spire, Bruno" sort="Spire, Bruno" uniqKey="Spire B" first="Bruno" last="Spire">Bruno Spire</name>
</author>
<author><name sortKey="Michel, Laurent" sort="Michel, Laurent" uniqKey="Michel L" first="Laurent" last="Michel">Laurent Michel</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2012">2012</date>
<idno type="RBID">pubmed:22544079</idno>
<idno type="pmid">22544079</idno>
<idno type="doi">10.3851/IMP2102</idno>
<idno type="wicri:Area/Main/Corpus">001569</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">001569</idno>
<idno type="wicri:Area/Main/Curation">001569</idno>
<idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">001569</idno>
<idno type="wicri:Area/Main/Exploration">001569</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Incidence, medical and socio-behavioural predictors of psychiatric events in an 11-year follow-up of HIV-infected patients on antiretroviral therapy.</title>
<author><name sortKey="Protopopescu, Camelia" sort="Protopopescu, Camelia" uniqKey="Protopopescu C" first="Camelia" last="Protopopescu">Camelia Protopopescu</name>
<affiliation wicri:level="3"><nlm:affiliation>INSERM, U912 (SESSTIM), Marseille, France. camelia.protopopescu@inserm.fr</nlm:affiliation>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U912 (SESSTIM), Marseille</wicri:regionArea>
<placeName><region type="region">Provence-Alpes-Côte d'Azur</region>
<region type="old region">Provence-Alpes-Côte d'Azur</region>
<settlement type="city">Marseille</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Raffi, Francois" sort="Raffi, Francois" uniqKey="Raffi F" first="François" last="Raffi">François Raffi</name>
</author>
<author><name sortKey="Brunet Francois, Cecile" sort="Brunet Francois, Cecile" uniqKey="Brunet Francois C" first="Cécile" last="Brunet-François">Cécile Brunet-François</name>
</author>
<author><name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name>
</author>
<author><name sortKey="Verdon, Renaud" sort="Verdon, Renaud" uniqKey="Verdon R" first="Renaud" last="Verdon">Renaud Verdon</name>
</author>
<author><name sortKey="Reboud, Philippe" sort="Reboud, Philippe" uniqKey="Reboud P" first="Philippe" last="Reboud">Philippe Reboud</name>
</author>
<author><name sortKey="Carrieri, Maria Patrizia" sort="Carrieri, Maria Patrizia" uniqKey="Carrieri M" first="Maria Patrizia" last="Carrieri">Maria Patrizia Carrieri</name>
</author>
<author><name sortKey="Leport, Catherine" sort="Leport, Catherine" uniqKey="Leport C" first="Catherine" last="Leport">Catherine Leport</name>
</author>
<author><name sortKey="Spire, Bruno" sort="Spire, Bruno" uniqKey="Spire B" first="Bruno" last="Spire">Bruno Spire</name>
</author>
<author><name sortKey="Michel, Laurent" sort="Michel, Laurent" uniqKey="Michel L" first="Laurent" last="Michel">Laurent Michel</name>
</author>
</analytic>
<series><title level="j">Antiviral therapy</title>
<idno type="eISSN">2040-2058</idno>
<imprint><date when="2012" type="published">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult (MeSH)</term>
<term>CD4 Lymphocyte Count (MeSH)</term>
<term>Depression (epidemiology)</term>
<term>Depression (psychology)</term>
<term>Drug Therapy, Combination (methods)</term>
<term>Female (MeSH)</term>
<term>Follow-Up Studies (MeSH)</term>
<term>France (epidemiology)</term>
<term>HIV (pathogenicity)</term>
<term>HIV Infections (epidemiology)</term>
<term>HIV Infections (psychology)</term>
<term>HIV Protease Inhibitors (pharmacology)</term>
<term>Humans (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Longitudinal Studies (MeSH)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Proportional Hazards Models (MeSH)</term>
<term>Risk Factors (MeSH)</term>
<term>Social Behavior (MeSH)</term>
<term>Suicide (psychology)</term>
<term>Suicide (statistics & numerical data)</term>
<term>Surveys and Questionnaires (MeSH)</term>
<term>Treatment Outcome (MeSH)</term>
<term>Viral Load (MeSH)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Association de médicaments (méthodes)</term>
<term>Charge virale (MeSH)</term>
<term>Comportement social (MeSH)</term>
<term>Dépression (psychologie)</term>
<term>Dépression (épidémiologie)</term>
<term>Enquêtes et questionnaires (MeSH)</term>
<term>Facteurs de risque (MeSH)</term>
<term>Femelle (MeSH)</term>
<term>France (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Incidence (MeSH)</term>
<term>Infections à VIH (psychologie)</term>
<term>Infections à VIH (épidémiologie)</term>
<term>Inhibiteurs de protéase du VIH (pharmacologie)</term>
<term>Modèles des risques proportionnels (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Numération des lymphocytes CD4 (MeSH)</term>
<term>Résultat thérapeutique (MeSH)</term>
<term>Suicide (psychologie)</term>
<term>Suicide (statistiques et données numériques)</term>
<term>VIH (Virus de l'Immunodéficience Humaine) (pathogénicité)</term>
<term>Études de suivi (MeSH)</term>
<term>Études longitudinales (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>HIV Protease Inhibitors</term>
</keywords>
<keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Depression</term>
<term>HIV Infections</term>
</keywords>
<keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Drug Therapy, Combination</term>
</keywords>
<keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Association de médicaments</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>HIV</term>
</keywords>
<keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>VIH (Virus de l'Immunodéficience Humaine)</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Inhibiteurs de protéase du VIH</term>
</keywords>
<keywords scheme="MESH" qualifier="psychologie" xml:lang="fr"><term>Dépression</term>
<term>Infections à VIH</term>
<term>Suicide</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Depression</term>
<term>HIV Infections</term>
<term>Suicide</term>
</keywords>
<keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Suicide</term>
</keywords>
<keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Suicide</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Dépression</term>
<term>France</term>
<term>Infections à VIH</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>CD4 Lymphocyte Count</term>
<term>Female</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Incidence</term>
<term>Longitudinal Studies</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Proportional Hazards Models</term>
<term>Risk Factors</term>
<term>Social Behavior</term>
<term>Surveys and Questionnaires</term>
<term>Treatment Outcome</term>
<term>Viral Load</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Charge virale</term>
<term>Comportement social</term>
<term>Enquêtes et questionnaires</term>
<term>Facteurs de risque</term>
<term>Femelle</term>
<term>Humains</term>
<term>Incidence</term>
<term>Modèles des risques proportionnels</term>
<term>Mâle</term>
<term>Numération des lymphocytes CD4</term>
<term>Résultat thérapeutique</term>
<term>Études de suivi</term>
<term>Études longitudinales</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>Psychiatric disorders are relatively common among HIV-infected patients. However, there are few studies about their potential risk factors. This analysis aimed to measure the incidence of severe psychiatric events (PE) among patients receiving combination antiretroviral therapy (cART) of the French APROCO-COPILOTE (ANRS CO8) cohort, and to identify the medical and socio-behavioural correlates of their first episode of depression, suicide or suicide attempt (D/S/SA).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>METHODS</b>
</p>
<p>APROCO-COPILOTE is a cohort of patients started on a protease inhibitor regimen between 1997 and 1999, with prospective medical standardized records and self-administered questionnaires collecting socio-demographic and socio-behavioural data. This analysis included all 11-year follow-up visits for 1,095 patients having completed baseline self-administered questionnaires. A proportional hazard Cox model was used to identify the correlates of a first D/S/SA event.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>The overall prevalence of severe PE remained low: 50 patients experienced 67 events (incidence rate [95% CI] =1.04 [0.82, 1.32] per 100 person-years). Depression (n=16), suicides (n=5) and suicide attempts (n=14) were the most frequently diagnosed PE (0.54 [0.39, 0.76] per 100 person-years) among 25 patients. Multivariate results showed that unemployment, unstable housing, detectable viral load and smoking more than 20 cigarettes/day were independently associated with D/S/SA.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b>
</p>
<p>Although the incidence of severe PE remained relatively low among the patients of APROCO-COPILOTE cohort, this study's results underline a clinically important problem in HIV-infected patients receiving cART. Furthermore, our findings not only emphasize the importance of comprehensive care, especially for socially vulnerable patients, but may also help future studies designed to assess the effectiveness of interventions in reducing the risk of PE during cART.</p>
</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22544079</PMID>
<DateCompleted><Year>2013</Year>
<Month>01</Month>
<Day>10</Day>
</DateCompleted>
<DateRevised><Year>2015</Year>
<Month>11</Month>
<Day>19</Day>
</DateRevised>
<Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2040-2058</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>17</Volume>
<Issue>6</Issue>
<PubDate><Year>2012</Year>
</PubDate>
</JournalIssue>
<Title>Antiviral therapy</Title>
<ISOAbbreviation>Antivir Ther</ISOAbbreviation>
</Journal>
<ArticleTitle>Incidence, medical and socio-behavioural predictors of psychiatric events in an 11-year follow-up of HIV-infected patients on antiretroviral therapy.</ArticleTitle>
<Pagination><MedlinePgn>1079-83</MedlinePgn>
</Pagination>
<ELocationID EIdType="doi" ValidYN="Y">10.3851/IMP2102</ELocationID>
<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Psychiatric disorders are relatively common among HIV-infected patients. However, there are few studies about their potential risk factors. This analysis aimed to measure the incidence of severe psychiatric events (PE) among patients receiving combination antiretroviral therapy (cART) of the French APROCO-COPILOTE (ANRS CO8) cohort, and to identify the medical and socio-behavioural correlates of their first episode of depression, suicide or suicide attempt (D/S/SA).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">APROCO-COPILOTE is a cohort of patients started on a protease inhibitor regimen between 1997 and 1999, with prospective medical standardized records and self-administered questionnaires collecting socio-demographic and socio-behavioural data. This analysis included all 11-year follow-up visits for 1,095 patients having completed baseline self-administered questionnaires. A proportional hazard Cox model was used to identify the correlates of a first D/S/SA event.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The overall prevalence of severe PE remained low: 50 patients experienced 67 events (incidence rate [95% CI] =1.04 [0.82, 1.32] per 100 person-years). Depression (n=16), suicides (n=5) and suicide attempts (n=14) were the most frequently diagnosed PE (0.54 [0.39, 0.76] per 100 person-years) among 25 patients. Multivariate results showed that unemployment, unstable housing, detectable viral load and smoking more than 20 cigarettes/day were independently associated with D/S/SA.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Although the incidence of severe PE remained relatively low among the patients of APROCO-COPILOTE cohort, this study's results underline a clinically important problem in HIV-infected patients receiving cART. Furthermore, our findings not only emphasize the importance of comprehensive care, especially for socially vulnerable patients, but may also help future studies designed to assess the effectiveness of interventions in reducing the risk of PE during cART.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Protopopescu</LastName>
<ForeName>Camelia</ForeName>
<Initials>C</Initials>
<AffiliationInfo><Affiliation>INSERM, U912 (SESSTIM), Marseille, France. camelia.protopopescu@inserm.fr</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Raffi</LastName>
<ForeName>François</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Brunet-François</LastName>
<ForeName>Cécile</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Salmon</LastName>
<ForeName>Dominique</ForeName>
<Initials>D</Initials>
</Author>
<Author ValidYN="Y"><LastName>Verdon</LastName>
<ForeName>Renaud</ForeName>
<Initials>R</Initials>
</Author>
<Author ValidYN="Y"><LastName>Reboud</LastName>
<ForeName>Philippe</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><LastName>Carrieri</LastName>
<ForeName>Maria Patrizia</ForeName>
<Initials>MP</Initials>
</Author>
<Author ValidYN="Y"><LastName>Leport</LastName>
<ForeName>Catherine</ForeName>
<Initials>C</Initials>
</Author>
<Author ValidYN="Y"><LastName>Spire</LastName>
<ForeName>Bruno</ForeName>
<Initials>B</Initials>
</Author>
<Author ValidYN="Y"><LastName>Michel</LastName>
<ForeName>Laurent</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><CollectiveName>APROCO-COPILOTE (ANRS CO8) Study Group</CollectiveName>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType>
</PublicationTypeList>
<ArticleDate DateType="Electronic"><Year>2012</Year>
<Month>04</Month>
<Day>27</Day>
</ArticleDate>
</Article>
<MedlineJournalInfo><Country>England</Country>
<MedlineTA>Antivir Ther</MedlineTA>
<NlmUniqueID>9815705</NlmUniqueID>
<ISSNLinking>1359-6535</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D017320">HIV Protease Inhibitors</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D018791" MajorTopicYN="N">CD4 Lymphocyte Count</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003863" MajorTopicYN="N">Depression</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D004359" MajorTopicYN="N">Drug Therapy, Combination</DescriptorName>
<QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005602" MajorTopicYN="N" Type="Geographic">France</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006678" MajorTopicYN="N">HIV</DescriptorName>
<QualifierName UI="Q000472" MajorTopicYN="N">pathogenicity</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015658" MajorTopicYN="N">HIV Infections</DescriptorName>
<QualifierName UI="Q000453" MajorTopicYN="Y">epidemiology</QualifierName>
<QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D017320" MajorTopicYN="N">HIV Protease Inhibitors</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015994" MajorTopicYN="N">Incidence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008137" MajorTopicYN="N">Longitudinal Studies</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016016" MajorTopicYN="N">Proportional Hazards Models</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012307" MajorTopicYN="N">Risk Factors</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D012919" MajorTopicYN="Y">Social Behavior</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013405" MajorTopicYN="N">Suicide</DescriptorName>
<QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName>
<QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D019562" MajorTopicYN="N">Viral Load</DescriptorName>
</MeshHeading>
</MeshHeadingList>
<InvestigatorList><Investigator ValidYN="Y"><LastName>Leport</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Raffi</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chêne</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Salamon</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Moatti</LastName>
<ForeName>J-P</ForeName>
<Initials>JP</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Pierret</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Spire</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Brun-Vézinet</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Fleury</LastName>
<ForeName>H</ForeName>
<Initials>H</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Masquelier</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Peytavin</LastName>
<ForeName>G</ForeName>
<Initials>G</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garraffo</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Costagliola</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dellamonica</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Katlama</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Meyer</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Salmon</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Sobel</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cuzin</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Dupon</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Duval</LastName>
<ForeName>X</ForeName>
<Initials>X</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Le Moing</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marchou</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>May</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rabaud</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Waldner-Combernoux</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Reboud</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Couffin-Cadiergues</LastName>
<ForeName>Sandrine</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marchand</LastName>
<ForeName>Lucie</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bouteloup</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bouhnik</LastName>
<ForeName>A D</ForeName>
<Initials>AD</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Brunet-Françoise</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Carrieri</LastName>
<ForeName>M P</ForeName>
<Initials>MP</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Courcoul</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Couturier</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Habak</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hardel</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Kurkdji</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Martiren</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Préau</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Protopopescu</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Surzyn</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Tabbal</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Taieb</LastName>
<ForeName>A</ForeName>
<Initials>A</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Villes</LastName>
<ForeName>V</ForeName>
<Initials>V</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Schmit</LastName>
<ForeName>J L</ForeName>
<Initials>JL</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Chennebault</LastName>
<ForeName>J M</ForeName>
<Initials>JM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Faller</LastName>
<ForeName>J P</ForeName>
<Initials>JP</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Mgy-Bertrand</LastName>
<ForeName>N</ForeName>
<Initials>N</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Hoen</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Drobachef</LastName>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bouchaud</LastName>
<ForeName>O</ForeName>
<Initials>O</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Granier</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Garré</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Verdon</LastName>
<ForeName>R</ForeName>
<Initials>R</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Perronne</LastName>
<ForeName>D C</ForeName>
<Initials>DC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Froguel</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Ceccaldi</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Peyramound</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Arsac</LastName>
<ForeName>P</ForeName>
<Initials>P</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bouvet</LastName>
<ForeName>E</ForeName>
<Initials>E</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bricaire</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bergmann</LastName>
<ForeName>J F</ForeName>
<Initials>JF</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Cabane</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Monsonego</LastName>
<ForeName>J</ForeName>
<Initials>J</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Girard</LastName>
<ForeName>P M</ForeName>
<Initials>PM</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Guillevin</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Herson</LastName>
<ForeName>S</ForeName>
<Initials>S</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Leport</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Jaussaud</LastName>
<ForeName>M C</ForeName>
<Initials>MC</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Michelet</LastName>
<ForeName>C</ForeName>
<Initials>C</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Lucht</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Debord</LastName>
<ForeName>T</ForeName>
<Initials>T</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Rey</LastName>
<ForeName>D</ForeName>
<Initials>D</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>De Jaureguiberry</LastName>
<ForeName>J P</ForeName>
<Initials>JP</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Marchou</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
</Investigator>
<Investigator ValidYN="Y"><LastName>Bernard</LastName>
<ForeName>L</ForeName>
<Initials>L</Initials>
</Investigator>
</InvestigatorList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="accepted"><Year>2011</Year>
<Month>11</Month>
<Day>25</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>2012</Year>
<Month>5</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="pubmed"><Year>2012</Year>
<Month>5</Month>
<Day>1</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2013</Year>
<Month>1</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">22544079</ArticleId>
<ArticleId IdType="doi">10.3851/IMP2102</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>France</li>
</country>
<region><li>Provence-Alpes-Côte d'Azur</li>
</region>
<settlement><li>Marseille</li>
</settlement>
</list>
<tree><noCountry><name sortKey="Brunet Francois, Cecile" sort="Brunet Francois, Cecile" uniqKey="Brunet Francois C" first="Cécile" last="Brunet-François">Cécile Brunet-François</name>
<name sortKey="Carrieri, Maria Patrizia" sort="Carrieri, Maria Patrizia" uniqKey="Carrieri M" first="Maria Patrizia" last="Carrieri">Maria Patrizia Carrieri</name>
<name sortKey="Leport, Catherine" sort="Leport, Catherine" uniqKey="Leport C" first="Catherine" last="Leport">Catherine Leport</name>
<name sortKey="Michel, Laurent" sort="Michel, Laurent" uniqKey="Michel L" first="Laurent" last="Michel">Laurent Michel</name>
<name sortKey="Raffi, Francois" sort="Raffi, Francois" uniqKey="Raffi F" first="François" last="Raffi">François Raffi</name>
<name sortKey="Reboud, Philippe" sort="Reboud, Philippe" uniqKey="Reboud P" first="Philippe" last="Reboud">Philippe Reboud</name>
<name sortKey="Salmon, Dominique" sort="Salmon, Dominique" uniqKey="Salmon D" first="Dominique" last="Salmon">Dominique Salmon</name>
<name sortKey="Spire, Bruno" sort="Spire, Bruno" uniqKey="Spire B" first="Bruno" last="Spire">Bruno Spire</name>
<name sortKey="Verdon, Renaud" sort="Verdon, Renaud" uniqKey="Verdon R" first="Renaud" last="Verdon">Renaud Verdon</name>
</noCountry>
<country name="France"><region name="Provence-Alpes-Côte d'Azur"><name sortKey="Protopopescu, Camelia" sort="Protopopescu, Camelia" uniqKey="Protopopescu C" first="Camelia" last="Protopopescu">Camelia Protopopescu</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/AutomedicationFrancoV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001584 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001584 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= AutomedicationFrancoV1 |flux= Main |étape= Exploration |type= RBID |clé= pubmed:22544079 |texte= Incidence, medical and socio-behavioural predictors of psychiatric events in an 11-year follow-up of HIV-infected patients on antiretroviral therapy. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22544079" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \ | NlmPubMed2Wicri -a AutomedicationFrancoV1
This area was generated with Dilib version V0.6.38. |